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Possible prebiotic significance of polyamines in the condensation, protection, encapsulation, and biological properties of DNAWhile DNA which has undergone ionic condensation with Co(3+)(NH3)6 is resistant to the action of the endonuclase DNAse I, in much the same way as DNA condensed with spermidine, it was significantly less active in transcription with the E. coli RNA polymerase than DNA-spermidine condensed forms. Although both compacted forms of DNA were more efficiently encapsulated into neutral liposomes, negatively charged liposomes were seldom formed in the presence of the present, positive ion-condensed DNA; spermidine is accordingly proposed as a plausible prebiotic DNA-condensing agent. Attention is given to the relevance of the polyimide-nucleic acids complexes in the evolution of life.
Document ID
19920062029
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Baeza, Isabel
(NASA Headquarters Washington, DC United States)
Ibanez, Miguel
(NASA Headquarters Washington, DC United States)
Wong, Carlos
(Escuela Nacional de Ciencias Biologicas Mexico City, Mexico)
Chavez, Pedro
(NASA Headquarters Washington, DC United States)
Gariglio, Patricio
(Instituto Politecnico Nacional, Mexico City, Mexico)
Oro, J.
(Houston, University TX, United States)
Date Acquired
August 15, 2013
Publication Date
January 1, 1992
Publication Information
Publication: Origins of Life and Evolution of the Biosphere
Volume: 21
Issue: 4 19
ISSN: 0169-6149
Subject Category
Space Biology
Accession Number
92A44653
Funding Number(s)
CONTRACT_GRANT: NGR-44-005-002
Distribution Limits
Public
Copyright
Other

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