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Polymer degradation and ultrafine particles - Potential inhalation hazards for astronautsTo test the hypothesis that exposure to ultrafine particles results in an increased interstiatilization of the particles which is accompanied by an acute pathological inflammation, rats were exposed to titanium dioxide (TiO2) particles by intratracheal instillation and by inhalation. Both acute intratracheal instillation and subchronic inhalation studies on rats show that ultrafine TiO2 particles access the pulmonary interstitium to a larger extent than fine particles and that they elicit an inflammatory response as indicated by PMN increase in lavaged cells. The release of ultrafine particles into the air of an enclosed environment from a thermodegradation event or from other sources is a potential hazard for astronauts. Knowing the mechanisms of action is a prerequisite for technical or medical countermeasures.
Document ID
19920067564
Document Type
Reprint (Version printed in journal)
Authors
Ferin, J. (NASA Headquarters Washington, DC United States)
Oberdoerster, G. (Rochester, University NY, United States)
Date Acquired
August 15, 2013
Publication Date
July 1, 1992
Publication Information
Publication: Acta Astronautica
Volume: 27
ISSN: 0094-5765
Subject Category
AEROSPACE MEDICINE
Funding Number(s)
CONTRACT_GRANT: NAGW-2356
CONTRACT_GRANT: NIH-ES-01247
CONTRACT_GRANT: NIH-ES-04872
Distribution Limits
Public
Copyright
Other

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