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Ventral horn cell responses to spaceflight and hindlimb suspensionVentral horn cells of the lumbosacral enlargement of the spinal cord were studied focusing on the succinate dehydrogenase (SDH) activity and cross-sectional area of the soma of ventral horn cells which were measured using a computer-aided image-processing system. The relationships between the soma size and SDH activities of lumber ventral horn cells after 14 days of spaceflight (Cosmos 2044) or of hindlimb suspension are considered. Three groups of rats under consideration include control, 14-day spaceflight, and 14-day hindlimb suspension. Data obtained indicate that, compared to the control group, the population distribution of SDH activities in the flight rats shifted toward higher activities, whereas in the suspended rats the distribution shifted toward lower activities. The interactive effects within individual cells showed that there was a higher percentage of small cells with high SDH activities in the flight than in the control or suspended rats. It is suggested that changes in ventral horn cells were due to factors other than simply the absence of weight support.
Document ID
19920068862
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Jiang, Bian
(NASA Ames Research Center Moffett Field, CA, United States)
Roy, Roland R.
(NASA Ames Research Center Moffett Field, CA, United States)
Poliakov, I. V.
(NASA Ames Research Center Moffett Field, CA, United States)
Krasnov, I. B.
(NASA Ames Research Center Moffett Field, CA, United States)
Edgerton, V. R.
(California, University Los Angeles; Medical Institute, Voronezh; Institute of Biomedical Problems, Moscow, Russia)
Date Acquired
August 15, 2013
Publication Date
August 1, 1992
Publication Information
Publication: Journal of Applied Physiology, Supplement
Volume: 73
Issue: 2 Au
ISSN: 8750-7587
Subject Category
Life Sciences (General)
Accession Number
92A51486
Funding Number(s)
CONTRACT_GRANT: NCC2-535
Distribution Limits
Public
Copyright
Other

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