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Effects of spaceflight on hypothalamic peptide systems controlling pituitary growth hormone dynamicsPossible effects of reduced gravity on central hypophysiotropic systems controlling growth hormone (GH) secretion were investigated in rats flown on Cosmos 1887 and 2044 biosatellites. Immunohistochemical (IHC)staining for the growth hormone-releasing factor (GRF), somatostatin (SS), and other hypothalamic hormones was performed on hypothalami obtained from rats. IHC analysis was complemented by quantitative in situ assessments of mRNAs encoding the precursors for these hormones. Data obtained suggest that exposure to microgravity causes a preferential reduction in GRF peptide and mRNA levels in hypophysiotropic neurons, which may contribute to impared GH secretion in animals subjected to spaceflight. Effects of weightlessness are not mimicked by hindlimb suspension in this system.
Document ID
19920068870
Document Type
Reprint (Version printed in journal)
Authors
Sawchenko, P. E. (NASA Ames Research Center Moffett Field, CA, United States)
Arias, C. (NASA Ames Research Center Moffett Field, CA, United States)
Krasnov, I. (NASA Ames Research Center Moffett Field, CA, United States)
Grindeland, R. E. (NASA Ames Research Center Moffett Field, CA, United States)
Vale, W. (Salk Institute for Biological Studies; Clayton Foundation for Research, La Jolla; NASA, Ames Research Center Moffett Field, CA; Institute of Biomedical Problems, Moscow, Russia)
Date Acquired
August 15, 2013
Publication Date
August 1, 1992
Publication Information
Publication: Journal of Applied Physiology, Supplement
Volume: 73
Issue: 2 Au
ISSN: 8750-7587
Subject Category
LIFE SCIENCES (GENERAL)
Funding Number(s)
CONTRACT_GRANT: NIH-DK-26741
Distribution Limits
Public
Copyright
Other