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Effect of spaceflight on lymphocyte proliferation and interleukin-2 productionIn this study, inguinal lymp node lymphocytes from rats flown on the Cosmos 2044 mission were tested for proliferation and interleukin-2 (IL-2) production. Cells cultured with mitogenic lectins, phorbol ester, and calcium ionophore, or T-cell mitogen and lymphokine, were assayed for DNA synthesis by (H-3) thymidine incorporation. Lymphocytes incubated with a T-cell mitogen alone also were tested for IL-2 production. Proliferation of lymphocytes from flight rats was not significantly different from controls for any of the mitogens tested. Furthermore, lymph node lymphocytes from control and flown rats produced similar amounts of IL-23. Thus microgravity may act on lymphocytes in a tissue-specific manner, a new finding that could impact on the evaluation of spaceflight effects on immunocompetence.
Document ID
19920068874
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Nash, Patricia V.
(NASA Ames Research Center Moffett Field, CA, United States)
Konstantinova, Irina V.
(NASA Ames Research Center Moffett Field, CA, United States)
Fuchs, Boris B.
(NASA Ames Research Center Moffett Field, CA, United States)
Rakhmilevich, Alexandr L.
(NASA Ames Research Center Moffett Field, CA, United States)
Lesniak, A. T.
(NASA Ames Research Center Moffett Field, CA, United States)
Mastro, Andrea M.
(Pennsylvania State University University Park; Institute of Biomedical Problems; Russian Academy of Medical Sciences, Institute of, Russia)
Date Acquired
August 15, 2013
Publication Date
August 1, 1992
Publication Information
Publication: Journal of Applied Physiology, Supplement
Volume: 73
Issue: 2 Au
ISSN: 8750-7587
Subject Category
Life Sciences (General)
Accession Number
92A51498
Funding Number(s)
CONTRACT_GRANT: NAG2-599
Distribution Limits
Public
Copyright
Other

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