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Record Details

Record 20 of 1000
Spaceflight alters immune cell function and distribution
Author and Affiliation:
Sonnenfeld, Gerald(NASA Ames Research Center, Moffett Field, CA, United States)
Mandel, Adrian D.(NASA Ames Research Center, Moffett Field, CA, United States)
Konstantinova, Irina V.(NASA Ames Research Center, Moffett Field, CA, United States)
Berry, Wallace D.(NASA Ames Research Center, Moffett Field, CA, United States)
Taylor, Gerald R.(NASA Ames Research Center, Moffett Field, CA, United States)
Lesniak, A. T.(NASA Ames Research Center, Moffett Field, CA, United States)
Fuchs, Boris B.(NASA Ames Research Center, Moffett Field, CA, United States)
Rakhmilevich, Alexander L.(Louisville, University, KY, NASA, Ames Research Center)
Abstract: Experiments are described which were performed onboard Cosmos 2044 to determine spaceflight effects on immunologically important cell function and distribution. Results indicate that bone marrow cells from flown and suspended rats exhibited a decreased response to a granulocyte/monocyte colony-stimulating factor compared with the bone marrow cells from control rats. Bone marrow cells showed an increase in the percentage of cells expressing markers for helper T-cells in the myelogenous population and increased percentages of anti-asialo granulocyte/monocyte-1-bearing interleulin-2 receptor bearing pan T- and helper T-cells in the lymphocytic population.
Publication Date: Aug 01, 1992
Document ID:
19920068875
(Acquired Nov 22, 1995)
Accession Number: 92A51499
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Journal of Applied Physiology, Supplement (ISSN 8750-7587); 73; 2, Au
Publisher Information: United States
Contract/Grant/Task Num: NAG2-614
Organization Source: NASA Ames Research Center; Moffett Field, CA, United States
NASA Johnson Space Center; Houston, TX, United States
Description: 5p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: BONE MARROW; CELLS (BIOLOGY); IMMUNOLOGY; LEUKOCYTES; SPACE FLIGHT STRESS; EXOBIOLOGY; IMMUNE SYSTEMS; MICROGRAVITY; SUSPENDING (HANGING)
Imprint And Other Notes: Journal of Applied Physiology, Supplement (ISSN 8750-7587), vol. 73, no. 2, Aug. 1992, p. 191S-195S.
Availability Source: Other Sources
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