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Spaceflight alters immune cell function and distributionExperiments are described which were performed onboard Cosmos 2044 to determine spaceflight effects on immunologically important cell function and distribution. Results indicate that bone marrow cells from flown and suspended rats exhibited a decreased response to a granulocyte/monocyte colony-stimulating factor compared with the bone marrow cells from control rats. Bone marrow cells showed an increase in the percentage of cells expressing markers for helper T-cells in the myelogenous population and increased percentages of anti-asialo granulocyte/monocyte-1-bearing interleulin-2 receptor bearing pan T- and helper T-cells in the lymphocytic population.
Document ID
19920068875
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Sonnenfeld, Gerald
(NASA Ames Research Center Moffett Field, CA, United States)
Mandel, Adrian D.
(NASA Ames Research Center Moffett Field, CA, United States)
Konstantinova, Irina V.
(NASA Ames Research Center Moffett Field, CA, United States)
Berry, Wallace D.
(NASA Ames Research Center Moffett Field, CA, United States)
Taylor, Gerald R.
(NASA Ames Research Center Moffett Field, CA, United States)
Lesniak, A. T.
(NASA Ames Research Center Moffett Field, CA, United States)
Fuchs, Boris B.
(NASA Ames Research Center Moffett Field, CA, United States)
Rakhmilevich, Alexander L.
(Louisville, University, KY; NASA, Ames Research Center Moffett Field, CA; NASA, Johnson Space Center, Houston, TX; Institute of Biomedical Problems; Russia, Russia)
Date Acquired
August 15, 2013
Publication Date
August 1, 1992
Publication Information
Publication: Journal of Applied Physiology, Supplement
Volume: 73
Issue: 2 Au
ISSN: 8750-7587
Subject Category
Life Sciences (General)
Accession Number
92A51499
Funding Number(s)
CONTRACT_GRANT: NAG2-614
Distribution Limits
Public
Copyright
Other

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