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Effect of spaceflight on natural killer cell activityThe effects of spaceflight on immune cell function were determined in rats flown on Cosmos 2044. Control groups included vivarium, synchronous, and antiorthostatically suspended rats. The ability of natural killer cells to lyse two different target cell lines was determined. Spleen and bone marrow cells obtained from flight rats showed significantly inhibited cytotoxicity for YAC-1 target cells compared with cells from synchronous control rats. This could have been due to exposure of the rats to microgravity. Antiorthostatic suspension did not affect the level of cytotoxicity from spleen cells of suspended rats for YAC-1 cells. On the other hand, cells from rats flown in space showed no significant differences from vivarium and synchronous control rats in cytotoxicity for K-562 target cells. Binding of natural killer cells to K-562 target cells was unaffected by spaceflight. Antiorthostatic suspension resulted in higher levels of cytotoxicity from spleen cells for Cr-51-labeled K-562 cells. The results indicate differential effects of spaceflight on function of natural killer cells. This shows that spaceflight has selective effects on the immune response.
Document ID
19920068876
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Rykova, Marina P.
(NASA Lyndon B. Johnson Space Center Houston, TX, United States)
Sonnenfeld, Gerald
(NASA Lyndon B. Johnson Space Center Houston, TX, United States)
Lesniak, A. T.
(NASA Lyndon B. Johnson Space Center Houston, TX, United States)
Taylor, Gerald R.
(NASA Lyndon B. Johnson Space Center Houston, TX, United States)
Meshkov, Dimitrii O.
(NASA Lyndon B. Johnson Space Center Houston, TX, United States)
Mandel, Adrian D.
(NASA Lyndon B. Johnson Space Center Houston, TX, United States)
Medvedev, Andrei E.
(NASA Lyndon B. Johnson Space Center Houston, TX, United States)
Berry, Wallace D.
(NASA Lyndon B. Johnson Space Center Houston, TX, United States)
Fuchs, Boris B.
(NASA Lyndon B. Johnson Space Center Houston, TX, United States)
Konstantinova, Irina V.
(Institute of Biomedical Problems; Russian Academy of Medical Sciences, Institute of Human Morphology, Moscow, Russia; Louisville, University, KY; NASA, Johnson Space Center Houston, TX; NASA, Ames Research Center, Moffett Field, CA, United States)
Date Acquired
August 15, 2013
Publication Date
August 1, 1992
Publication Information
Publication: Journal of Applied Physiology, Supplement
Volume: 73
Issue: 2 Au
ISSN: 8750-7587
Subject Category
Life Sciences (General)
Accession Number
92A51500
Funding Number(s)
CONTRACT_GRANT: NAG2-614
Distribution Limits
Public
Copyright
Other

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