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Rapid increase of inositol 1,4,5-trisphosphate in the HeLa cells after hypergravity exposureThe IP3 level in HeLa cells has been elevated through the application in hypergravity in a time-dependent manner. The data obtained for the hydrolytic products of PIP2, IP3, and DG are noted to modulate c-myc gene expression. It is also established that the cAMP accumulation by the IBMX in hypergravity-exposed cells was suppressed relative to the control. In light of IP3 increase and cAMP decrease results, a single GTP-binding protein may play a role in the hypergravity signal transduction of HeLa cells by stimulating PLC while inhibiting adenylate cyclase.
Document ID
Document Type
Conference Paper
Kumei, Yasuhiro
(Tokyo Medical and Dental University Japan)
Whitson, Peggy A.
(NASA Lyndon B. Johnson Space Center Houston, TX, United States)
Cintron, Nitza M.
(NASA Johnson Space Center Houston, TX, United States)
Sato, Atsushige
(Tokyo Medical and Dental University Japan)
Date Acquired
August 15, 2013
Publication Date
January 1, 1990
Subject Category
Life Sciences (General)
Meeting Information
International Symposium on Space Technology and Science(Tokyo)
Accession Number
Distribution Limits

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