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New pharmacologic approaches to the prevention of space/motion sicknessThree fundamental approaches used in the selection of new agents for the evaluation in the prevention of space-motion sickness (SMS) are reviewed, with emphasis on drugs under investigation at the Johnson Space Center. These approaches are: (1) the selection of agents from drug classes that possess pharmacologic properties of established antimotion sickness agents, (2) the selection of drugs that are used to prevent emesis caused by means other than the exposure to motion, and (3) basic research that characterizes individual differences in susceptibility to SMS. In the latter type of studies, it was found that subjects who were more resistant to SMS had higher plasma AVP after severe nausea than subjects with lower resistance. The review details the experimental data collected on AVP and adrenocorticotropin. It is noted that data support interrelated roles for AVP and opioid peptides in SMS.
Document ID
19930033541
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Kohl, Randall L.
(Universities Space Research Association; NASA, Johnson Space Center Houston; Texas Univ., Galveston, United States)
Macdonald, Scott
(Universities Space Research Association; NASA, Johnson Space Center Houston, TX, United States)
Date Acquired
August 15, 2013
Publication Date
October 1, 1991
Publication Information
Publication: Journal of Clinical Pharmacology
Volume: 31
Issue: 10
ISSN: 0091-2700
Subject Category
Aerospace Medicine
Accession Number
93A17538
Funding Number(s)
CONTRACT_GRANT: NAS9-18128
PROJECT: RTOP 199-16-11-08
Distribution Limits
Public
Copyright
Other

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