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Optimal sampling theory and population modelling - Application to determination of the influence of the microgravity environment on drug distribution and eliminationThe optimal sampling theory is evaluated in applications to studies related to the distribution and elimination of several drugs (including ceftazidime, piperacillin, and ciprofloxacin), using the SAMPLE module of the ADAPT II package of programs developed by D'Argenio and Schumitzky (1979, 1988) and comparing the pharmacokinetic parameter values with results obtained by traditional ten-sample design. The impact of the use of optimal sampling was demonstrated in conjunction with NONMEM (Sheiner et al., 1977) approach, in which the population is taken as the unit of analysis, allowing even fragmentary patient data sets to contribute to population parameter estimates. It is shown that this technique is applicable in both the single-dose and the multiple-dose environments. The ability to study real patients made it possible to show that there was a bimodal distribution in ciprofloxacin nonrenal clearance.
Document ID
19930033545
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Drusano, George L.
(Maryland Univ. Baltimore, United States)
Date Acquired
August 15, 2013
Publication Date
October 1, 1991
Publication Information
Publication: Journal of Clinical Pharmacology
Volume: 31
Issue: 10
ISSN: 0091-2700
Subject Category
Aerospace Medicine
Accession Number
93A17542
Funding Number(s)
CONTRACT_GRANT: NAG9-249
Distribution Limits
Public
Copyright
Other

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