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Effects of insulin and exercise on rat hindlimb muscles after simulated microgravityThe effect of simulated microgravity on the insulin- and exercise-stimulated glucose uptake and metabolism in the hindlimb muscles of rats was investigated using three groups of rats suspended at 45 head-down tilt (SUS) for 14 days: (1) cage control, (2) exercising (treadmill running) control, and (3) rats subjected to suspension followed by exercise (SUS-E). It was found that the suspension of rats with hindlimbs non-weight bearing led to enhanced muscle responses to insulin and exercise, when these stimuli were applied separately. However, the insulin affect appeared to be impaired after exercise for the SUS-E rats, especially for the soleus muscle.
Document ID
19930036039
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Stump, Craig S.
(NASA Ames Research Center Moffett Field, CA, United States)
Balon, Thomas W.
(NASA Ames Research Center Moffett Field, CA, United States)
Tipton, Charles M.
(Arizona Univ. Tucson; Iowa Univ., Iowa City, United States)
Date Acquired
August 15, 2013
Publication Date
November 1, 1992
Publication Information
Publication: Journal of Applied Physiology
Volume: 73
Issue: 5
ISSN: 8750-7587
Subject Category
Life Sciences (General)
Accession Number
93A20036
Funding Number(s)
CONTRACT_GRANT: NGT-50493
CONTRACT_GRANT: NAG2-392
Distribution Limits
Public
Copyright
Other

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