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Regional changes in muscle mass following 17 weeks of bed restThis work reports on the muscle loss and recovery after 17 wk of continuous bed rest and 8 wk of reambulation in eight normal male volunteers. Muscle changes were assessed by urinary levels of 3-methylhistidine (3-MeH), nitrogen balance, dual-photon absorptiometry (DPA), magnetic resonance imaging (MRI), and isokinetic muscle performance. The total body lean tissue loss during bed rest calculated from nitrogen balance was 3.9 +/- 2.1 kg. Although the total loss is minimal, DPA scans showed that nearly all of the lean tissue loss occurred in the lower limbs. Similarly, MRI muscle volume measurements showed greater percent loss in the limbs relative to the back muscles. MRI, DPA, and nitrogen balance suggest that muscle atrophy continued throughout bed rest with rapid recovery after reambulaton. Isokinetic muscle strength decreased significantly in the thigh and calf with no loss in the arms and with rapid recovery during reambulation.
Document ID
19930036042
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Leblanc, Adrian D.
(NASA Lyndon B. Johnson Space Center Houston, TX, United States)
Schneider, Victor S.
(NASA Lyndon B. Johnson Space Center Houston, TX, United States)
Evans, Harlan J.
(NASA Lyndon B. Johnson Space Center Houston, TX, United States)
Pientok, Colette
(NASA Lyndon B. Johnson Space Center Houston, TX, United States)
Rowe, Roger
(NASA Lyndon B. Johnson Space Center Houston, TX, United States)
Spector, Elisabeth
(Baylor College of Medicine; NASA, Johnson Space Center; Krug Life Sciences, Houston TX, United States)
Date Acquired
August 15, 2013
Publication Date
November 1, 1992
Publication Information
Publication: Journal of Applied Physiology
Volume: 73
Issue: 5
ISSN: 8750-7587
Subject Category
Aerospace Medicine
Accession Number
93A20039
Funding Number(s)
CONTRACT_GRANT: NIH-RR-00350
CONTRACT_GRANT: NAG9-130
CONTRACT_GRANT: NIH-RR-02558
Distribution Limits
Public
Copyright
Other

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