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Rett syndrome - Stimulation of endogenous biogenic amines
Author and Affiliation:
Pelligra, R.(NASA Ames Research Center, Moffett Field, CA, United States)
Norton, R. D.(NASA Ames Research Center, Moffett Field, CA, United States)
Wilkinson, R.(NASA Ames Research Center, Moffett Field, CA, United States)
Leon, H. A.(NASA Ames Research Center, Moffett Field, CA, United States)
Matson, W. R.(NASA Ames Research Center, Moffett Field, CA, United States)
Abstract: Transient hypercapnic hyperoxemia was induced in two Rett syndrome children by the administration of a gaseous mixture of 80 percent O2 and 20 percent CO2. Time course studies of neurotransmitters and their metabolites showed an immediate and marked increase in central biogenic amine turnover following inhalation of the gas mixture. The increased turnover of biogenic amines was associated with improved clinical changes. This suggests a coupled relationship and provides further support for an etiological role of neurotransmitter dysfunction in Rett syndrome. In a complementary study, elevation of pulmonary CO2 by application of a simple rebreathing device resulted in improvement of abnormal blood gases and elimination of the Cheyne-Stokes-like respiratory pattern of the Rett syndrome. Near normalization of the EEG occurred when a normal respiratory pattern was imposed by means of a respirator. Taken together, these results lead to the preliminary conclusion that cerebral hypoxemia secondary to abnormal respiratory function may contribute to diminished production of biogenic amines in Rett syndrome.
Publication Date: Jun 01, 1992
Document ID:
19930044700
(Acquired Dec 28, 1995)
Accession Number: 93A28697
Subject Category: AEROSPACE MEDICINE
Document Type: Journal Article
Publication Information: Neuropediatrics (ISSN 0174-304X); 23; 3; p. 131-137.
Publisher Information: Germany
Financial Sponsor: NASA; United States
Organization Source: NASA Ames Research Center; Moffett Field, CA, United States
Description: 7p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: AMINES; ANOXIA; CARBON DIOXIDE CONCENTRATION; HUMAN PATHOLOGY; NEUROPHYSIOLOGY; OXYGEN; SIGNS AND SYMPTOMS; CHILDREN; HUMAN BEHAVIOR; NOREPINEPHRINE
Imprint And Other Notes: Neuropediatrics vol. 23, no. 3 p. 131-137. June 1992
Availability Source: Other Sources
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