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Alterations in biosynthetic accumulation of collagen types I and III during growth and morphogenesis of embryonic mouse salivary glandsWe examined the biosynthetic patterns of interstitial collagens in mouse embryonic submandibular and sublingual glands cultured in vitro. Rudiments explanted on day 13 of gestation and cultured for 24, 48, and 72 h all synthesized collagen types I, III, and V. However, while the total incorporation of label into collagenous proteins did not change over the three-day culture period, the rate of accumulation of newly synthesized types I and III did change. At 24 h, the ratio of newly synthesized collagen types I:III was approximately 2, whereas at 72 h, the ratio was approximately 5. These data suggest that collagen types I and III may be important in initiation of branching in this organ, but that type I may become dominant in the later stages of development and in maintenance of the adult organ.
Document ID
19930044749
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Hardman, P.
(NASA Headquarters Washington, DC United States)
Spooner, B. S.
(NASA Specialized Center of Research and Training in Gravitational Biology; Kansas State Univ. Manhattan, United States)
Date Acquired
August 16, 2013
Publication Date
September 1, 1992
Publication Information
Publication: International Journal of Developmental Biology
Volume: 36
Issue: 3
ISSN: 0214-6282
Subject Category
Life Sciences (General)
Accession Number
93A28746
Distribution Limits
Public
Copyright
Other

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