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Record Details

Record 66 of 2019
Treatment efficacy of intramuscular promethazine for Space Motion Sickness
Author and Affiliation:
Davis, Jeffrey R.(NASA Johnson Space Center, Houston)
Jennings, Richard T.(NASA Lyndon B. Johnson Space Center, Houston, TX, United States)
Beck, Bradley G.(NASA Lyndon B. Johnson Space Center, Houston, TX, United States)
Bagian, James P.(NASA Johnson Space Center, Houston, TX, United States)
Abstract: Intramuscular promethazine and its efficacy in the treatment of Space Motion Sickness (SMS) were evaluated using standardized questions administered during postflight debriefings to crewmembers immediately after their first Shuttle flight. The comparison showed that 25 percent of crewmembers treated with IM promethazine were 'sick' on flight day 2, compared to 50 percent of crewmembers who did not receive promethazine, 90 percent reported immediate symptom relief as well. Untreated crewmembers typically have slow symptom resolution over 72-96 h, and those treated with oral scopolamine/dextroamphetamine show delayed symptom development. This study suggests that intramuscular promethazine is an effective treatment for SMS and merits continued use and further controlled investigations.
Publication Date: Mar 01, 1993
Document ID:
19930046286
(Acquired Dec 28, 1995)
Accession Number: 93A30283
Subject Category: AEROSPACE MEDICINE
Document Type: Journal Article
Publication Information: Aviation, Space, and Environmental Medicine (ISSN 0095-6562); 64; 3; p. 230-233.
Publisher Information: United States
Financial Sponsor: NASA; United States
Organization Source: NASA Johnson Space Center; Houston, TX, United States
Description: 4p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: AEROSPACE ENVIRONMENTS; FLIGHT CREWS; MOTION SICKNESS DRUGS; PROMETHAZINE; NAUSEA; SPACE SHUTTLES; VOMITING
Imprint And Other Notes: Aviation, Space, and Environmental Medicine vol. 64, no. 3 p. 230-233. March 1993
Availability Source: Other Sources
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