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Record Details

Record 2 of 838
Alanine increases blood pressure during hypotension
Author and Affiliation:
Conlay, L. A.(MIT, Cambridge)
Maher, T. J.(MIT, Cambridge)
Wurtman, R. J.(MIT, Cambridge, MA, United States)
Abstract: The effect of L-alanine administration on blood pressure (BP) during haemorrhagic shock was investigated using anesthetized rats whose left carotid arteries were cannulated for BP measurement, blood removal, and drug administration. It was found that L-alanine, in doses of 10, 25, 50, 100, and 200 mg/kg, increased the systolic BP of hypotensive rats by 38 to 80 percent (while 100 mg/kg pyruvate increased BP by only 9.4 mmhg, not significantly different from saline). The results suggest that L-alanine might influence cardiovascular function.
Publication Date: Jan 01, 1990
Document ID:
19930049030
(Acquired Dec 28, 1995)
Accession Number: 93A33027
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Pharmacology & Toxicology (ISSN 0901-9928); p. 415, 416.
Publisher Information: Denmark
Contract/Grant/Task Num: NIH-R23-3026
Financial Sponsor: NASA; United States
Organization Source: NASA; Washington, DC, United States
Description: 2p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: ALANINE; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; HYPOTENSION; AMINO ACIDS; DOGS; RATS; SYSTOLIC PRESSURE
Imprint And Other Notes: Pharmacology & Toxicology vol. 66 p. 415, 416. 1990
Miscellaneous Notes: Research supported by NASA and USAF
Availability Source: Other Sources
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