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Effects of dietary amino acids, carbohydrates, and choline on neurotransmitter synthesisThe ability of a meal to increase or decrease brain neurotransmitter synthesis has been studied. It is concluded that brain serotonin synthesis is directly controlled by the proportions of carbohydrate to protein in meals and snacks that increase or decrease brain tryptophan levels, thereby changing the substrate saturation of tryptophan hydroxylase and the rate of serotonin synthesis. The ability of serotoninergic neurons to have their output coupled to dietary macronutrients enables them to function as sensors of peripheral metabolism, and to subserve an important role in the control of appetite. The robust and selective responses of catecholaminergic and cholinergic neurons to supplemental tyrosine and choline suggest that these compounds may become useful as a new type of drug for treating deseases or conditions in which adequate quantities of the transmitter would otherwise be unavailable.
Document ID
19930049034
Document Type
Reprint (Version printed in journal)
Authors
Wurtman, Richard J.
(MIT Cambridge, MA, United States)
Date Acquired
August 16, 2013
Publication Date
January 1, 1988
Publication Information
Publication: Mount Sinai Journal of Medicine
Volume: 55
Issue: 1
ISSN: 0027-2507
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NIH-RR-00088-24
CONTRACT_GRANT: AF-AFOSR-83-0366
CONTRACT_GRANT: NAG2-210
CONTRACT_GRANT: NIH-MH-28783
CONTRACT_GRANT: NIH-NS-21231
Distribution Limits
Public
Copyright
Other
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