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Record Details

Record 42 of 352
Tyrosine - Effects on catecholamine release
External Online Source: doi:10.1016/0361-9230(88)90161-X
Author and Affiliation:
Acworth, Ian N.(NASA, Washington, DC, United States)
During, Matthew J.(NASA, Washington, DC, United States)
Wurtman, Richard J.(MIT, Cambridge, MA, United States)
Abstract: Tyrosine administration elevates striatal levels of dopamine metabolites in animals given treatments that accelerate nigrostriatal firing, but not in untreated rats. We examined the possibility that the amino acid might actually enhance dopamine release in untreated animals, but that the technique of measuring striatal dopamine metabolism was too insensitive to demonstrate such an effect. Dopamine release was assessed directly, using brain microdialysis of striatal extracellular fluid. Tyrosine administration (50-200 mg/kg IP) did indeed cause a dose related increase in extracellular fluid dopamine levels with minor elevations in levels of DOPAC and HVA, its major metabolites, which were not dose-related. The rise in dopamine was short-lived, suggesting that receptor-mediated feedback mechanisms responded to the increased dopamine release by diminishing neuronal firing or sensitivity to tyrosine. These observations indicate that measurement of changes in striatal DOPAC and HVA, if negative, need not rule out increases in nigrostriatal dopamine release.
Publication Date: Jan 01, 1988
Document ID:
19930049041
(Acquired Dec 28, 1995)
Accession Number: 93A33038
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Brain Research Bulletin (ISSN 0361-9320); p. 473-477.
Publisher Information: United States
Financial Sponsor: NASA; United States
Organization Source: NASA; Washington, DC, United States
Description: 5p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: BRAIN; CATECHOLAMINE; DOPA; METABOLITES; NEUROPHYSIOLOGY; TYROSINE; BIOSYNTHESIS; ENZYME ACTIVITY; NEUROTRANSMITTERS; RATS; SYNAPSES
Imprint And Other Notes: Brain Research Bulletin vol. 21 p. 473-477. 1988
Miscellaneous Notes: Research supported by USAF, Center for Brain Sciences and Metabolism Charitable Trust, and NASA
Availability Source: Other Sources
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