Potential health effects of fume particles on the crew of spacecraftsThe effect of the size of polymer (e.g., Teflon) particles in fumes inhaled by spacecraft personnel on the condition of the lung tissue and on the recovery of the exposed subjects was investigated in rats receiving a single intrapulmonary instillation, or repeated inhalation exposures to either TiO2 particles with primary particle diameter 20 nm, or TiO2 particles with primary particle diameter 250 nm. It was found that rats exposed to 20-nm-diam particles showed a dramatically higher toxicity and slower recovery compared to the group exposed to the 250-nm-diam particles, due to a larger extent of penetration of the interstitium of the lung by the finer particles.
Document ID
19930057548
Acquisition Source
Legacy CDMS
Document Type
Conference Paper
Authors
Ferin, Juraj (NASA Headquarters Washington, DC United States)
Oberdorster, Gunter (Rochester Univ. NY, United States)
Date Acquired
August 16, 2013
Publication Date
July 1, 1992
Subject Category
Man/System Technology And Life Support
Report/Patent Number
SAE PAPER 921387
Meeting Information
Meeting: SAE, International Conference on Environmental Systems