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Potential health hazards from thermal degradation events - Particulate vs. gas phase effectsThe effect of instillation of ultrafine TiO2 particles (10-nm anatase-TiO2 and 12-nm rutile-TiO2 (administered in doses from 60 to 1000 microg/rat and 500 microg/rat, respectively) on the respiratory tract of exposed rats was compared to the effects of larger (250 nm anatase-TiO2 and 220-nm rutile-TiO2 particles (given in doses 500 or 1000 microg/rat and 500 microg/rat, respectively). These effects were also compared to the effects of inhalation of 20-nm and 250-nm anatase-TiO2 particles and inhalation with surrogate gas phase components (HF and HCl). It was found that ultrafine TiO2 particles induced greater inflammatory reaction in the lung, had greater adverse effect on alveolar macrophage-mediated clearance function, and had a greater potential to induce mediators which can adversely affect other lung cells than did larger-sized particles. Inhalation of surrogate gas phase components caused injury only to the upper respiratory tract, in contrast to the ultrafine particles, which affected the deep lung.
Document ID
19930057549
Acquisition Source
Legacy CDMS
Document Type
Conference Paper
Authors
Oberdorster, Gunter
(NASA Headquarters Washington, DC United States)
Ferin, Juraj
(NASA Headquarters Washington, DC United States)
Finkelstein, Jacob
(NASA Headquarters Washington, DC United States)
Baggs, Raymond
(Rochester Univ. NY, United States)
Stavert, D. M.
(NASA Headquarters Washington, DC United States)
Lehnert, Bruce E.
(Los Alamos National Lab. NM, United States)
Date Acquired
August 16, 2013
Publication Date
July 1, 1992
Subject Category
Aerospace Medicine
Report/Patent Number
SAE PAPER 921388
Meeting Information
Meeting: SAE, International Conference on Environmental Systems
Location: Seattle, WA
Country: United States
Start Date: July 13, 1992
End Date: July 16, 1992
Sponsors: SAE
Accession Number
93A41546
Funding Number(s)
CONTRACT_GRANT: NAGW-2356
Distribution Limits
Public
Copyright
Other

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