Transcapillary fluid responses to lower body negative pressure

The effect of lower body negative pressure (LBNP) on transcapillary fluid balance, with and without saline ingestion, was investigated in normally hydrated human subjects by measuring leg interstitial fluid pressure, leg circumference, plasma volume, and net whole body transcapillary fluid transport during and after supine LBNP in human subjects. The results indicate that prolonged LBNP, especially with saline ingestion, promotes fluid filtration into lower body tissues.