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Radiation effects in nematodes: Results from IML-1 experimentsThe nematode Caenorhabditis elegans was exposed to natural space radiation using the ESA biorack facility aboard Spacelab on International Microgravity Laboratory 1, STS-42. For the major experimental objective dormant animals were suspended in buffer or on agar or immobilized next to CR-39 plastic nuclear track detectors to correlate fluence of HZE particles with genetic events. This configuration was used to isolate mutations in a set of 350 essential genes as well as in the unc-22 structural gene. From flight samples 13 mutants in the unc-22 gene were isolated along with 53 lethal mutations from autosomal regions balanced by a translocation eT1(III;V). Preliminary analysis suggests that mutants from worms correlated with specific cosmic ray tracks may have a higher proportion of rearrangements than those isolated from tube cultures on a randomly sampled basis. Flight sample mutation rate was approximately 8-fold higher than ground controls which exhibited laboratory spontaneous frequencies.
Document ID
19940039031
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Nelson, G. A.
(Jet Propulsion Laboratory, Pasadena, CA US, United States)
Schubert, W. W.
(Jet Propulsion Laboratory, Pasadena, CA US, United States)
Kazarians, G. A.
(Jet Propulsion Laboratory, Pasadena, CA US, United States)
Richards, G. F.
(Jet Propulsion Laboratory, Pasadena, CA US, United States)
Benton, E. V.
(Univ. of San Francisco, San Francisco, CA US, United States)
Benton, E. R.
(Univ. of San Francisco, San Francisco, CA US, United States)
Henke, R.
(Univ. of San Francisco, San Francisco, CA US, United States)
Date Acquired
August 16, 2013
Publication Date
October 1, 1994
Publication Information
Publication: Life Sciences and Space Research 25 (2) Radiation Biology: Topical Meeting of the COSPAR Interdisciplinary Scientific Commission F of the COSPAR 29th Plenary Meeting, Washington, DC, Aug. 28-Sep. 5, 1
Volume: 14
Issue: 10
ISSN: 0273-1177
Subject Category
Life Sciences (General)
Accession Number
94A62480
Distribution Limits
Public
Copyright
Other

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