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Genetic and molecular dosimetry of HZE radiation (US-1 RADIAT)In order to estimate radiation exposure in space, experiments were conducted during the 1st International Microgravity Laboratory (IML-1) mission in order to isolate genetic changes in animal cells caused by cosmic rays. The space measurements were evaluated against results from synthetic cosmic rays produced by particle accelerators on the ground. The biological material used was the tiny soil nematode, Caenorhabditis elegans. The measurements were made by thermoluminescent detectors and plastic nuclear track detectors. The development and the chromosome mechanics in microgravity were studied, and the mutagenesis induced by radiation exposure was analyzed. The results showed that there are no obvious differences in the development, behavior and chromosome mechanics, as a function of gravity unloading (reproduction, self-fertilization and mating of males with hermaphrodites, gross anatomy, symmetry and gametogenesis, pairing, disjoining and recombination of chromosomes). A variety of mutants were isolated, and it was noted that mutants isolated from regions of identified high particles were more severely affected than those isolated by random screening. Linear energy transfer particles seem to favor large scale genetic lesions.
Document ID
19950026681
Document Type
Other
Authors
Nelson, Gregory A. (Jet Propulsion Lab., California Inst. of Tech. Pasadena, CA, United States)
Schubert, W. W. (Jet Propulsion Lab., California Inst. of Tech. Pasadena, CA, United States)
Kazarians, G. A. (Jet Propulsion Lab., California Inst. of Tech. Pasadena, CA, United States)
Richards, G. F. (Jet Propulsion Lab., California Inst. of Tech. Pasadena, CA, United States)
Benton, E. V. (San Francisco Univ. CA., United States)
Benton, E. R. (San Francisco Univ. CA., United States)
Henke, R. P. (San Francisco Univ. CA., United States)
Date Acquired
August 16, 2013
Publication Date
March 1, 1995
Publication Information
Publication: ESA, Biorack on Spacelab IML-1
Subject Category
MATERIALS PROCESSING
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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