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A bacteria antibiotic system in space (23-F ANTIBIO)In order to evaluate the effects of weightlessness and cosmic radiations on the bacteria resistance to antibiotics, the Antibio 23F experiment was undertaken onboard Discovery during the 1st International Microgravity Laboratory (IML-1) mission. The effects of various antibiotic concentrations (dihydrostreptomycin) on Escherichia coli growth and cell division behavior were studied. The antibiotic binding was investigated using a radioactive tracer (tritium). The results showed that microgravity did not affect E. coli cells in regards the growth and the cell division. The antibiotic added to the culture medium induced an inhibition of the cultures both in the flight and ground controls. However, the antibiotic was less efficient in flight. The behavior of bacteria was modified, and the exponential growth rate was increased in flight. The incorporation of radioactive antibiotics in flight was comparatively different to ground incorporation, which indicated some perturbations in antibiotic binding. The experiments performed in the 1 g centrifuge did not show any difference in the cultures developed on the static rack, and could support a radiative effect of cosmic radiation to explain the results.
Document ID
19950026682
Acquisition Source
Legacy CDMS
Document Type
Other
Authors
Tixador, Rene
(Toulouse Univ. France)
Gasset, G.
(Toulouse Univ. France)
Eche, B.
(Toulouse Univ. France)
Moatti, N.
(Centre Hospitalier Univ. Rangueil, Toulouse, France)
Lapchine, L.
(Centre Hospitalier Univ. Rangueil, Toulouse, France)
Woldringh, C.
(Amsterdam Univ. Netherlands)
Toorop, P.
(Amsterdam Univ. Netherlands)
Moatti, J. P.
(Toulouse Univ. France)
Delmotte, F.
(Centre National de la Recherche Scientifique Orleans, France)
Tap, G.
(Toulouse Univ. France)
Date Acquired
August 16, 2013
Publication Date
March 1, 1995
Publication Information
Publication: ESA, Biorack on Spacelab IML-1
Subject Category
Materials Processing
Accession Number
95N33103
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
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