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Production and action of cytokines in spaceB6MP102 cells, a continuously cultured murine bone marrow macrophage cell line, were tested for secretion of tumor necrosis factor-alpha and Interleukin-1 during space flight. We found that B6MP102 cells secreted more tumor necrosis factor-alpha and interleukin-1 when stimulated in space with lipopolysaccharide than controls similarly stimulated on earth. This compared to increased secretion of interferon-beta and -gamma by lymphocytes that was measured on the same shuttle flights. Although space flight enhanced B6MP102 secretion of tumor necrosis factor-alpha, an experiment on a subsequent space flight (STS-50) found that cellular cytotoxicity, mediated by tumor necrosis factor-alpha, was inhibited.
Document ID
19950029034
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Chapes, Stephen K.
(Kansas State Univ. Manhattan, KS, US, United States)
Morrison, Dennis R.
(NASA Johnson Space Center Houston, TX, US, United States)
Guikema, James A.
(Kansas State Univ. Manhattan, KS, US, United States)
Lewis, Marian L.
(Univ. of Alabama, Huntsville, AL US, United States)
Spooner, Brian S.
(Kansas State Univ. Manhattan, KS, US, United States)
Date Acquired
August 16, 2013
Publication Date
August 1, 1994
Publication Information
Publication: Life sciences and space research 25 (1). Gravitational biology; Interdisciplinary Scientific Commission F of the COSPAR Plenary Meeting, 29th, Washington, DC, Aug. 28-Sep. 5, 1992. A95-60632
Volume: 14
Issue: 8
ISBN: 0-08-042485-6
Subject Category
Life Sciences (General)
Accession Number
95A60633
Funding Number(s)
CONTRACT_GRANT: DAMD17-89-Z-9039
CONTRACT_GRANT: NAGW-2328
CONTRACT_GRANT: NAGW-1197
Distribution Limits
Public
Copyright
Other

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