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The Rhesus monkey as a model for testing the immunological effects of space flightThe Rhesus monkey has been proposed as a model for the effects of space flight on immunity. In order to determine the feasibility of the use of the Rhesus monkey as a model, we studied the use of Rhesus monkey cells for immunological procedures that have been shown to be affected by space flight in both rodents and humans. We have shown that both lymph node cells and peripheral blood leukocytes can be stained with monoclonal antibodies to detect the following surface markers: CD4, CD-8, Ia and surface immunoglobulin. Also, the level of Ia antigen expression was increased by treatment of the cells with human interferon-gamma. In addition, cells were induced to produce interferons and interleukins. Isolated neutrophils also demonstrated increased oxidative burst. These data indicate that the Rhesus monkey will be a useful model for space flight studies of immunity.
Document ID
19950029082
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Sonnenfeld, G.
(Univ. of Louisville, Louisville, KY US, United States)
Schaffar, L.
(Assoc-France de Lutte Cont. la Mucov Paris, France)
Schmitt, D. A.
(CHU de Toulouse-Rangueil Toulouse, France)
Peres, C.
(CHU de Toulouse-Rangueil Toulouse, France)
Miller, E. S.
(Univ. of Louisville, Louisville, KY US, United States)
Date Acquired
August 16, 2013
Publication Date
August 1, 1994
Publication Information
Publication: Life sciences and space research 25 (1). Gravitational biology; Interdisciplinary Scientific Commission F of the COSPAR Plenary Meeting, 29th, Washington, DC, Aug. 28-Sep. 5, 1992. A95-60632
Volume: 14
Issue: 8
ISSN: 0273-1177
ISBN: 0-08-042485-6
Subject Category
Aerospace Medicine
Accession Number
95A60681
Funding Number(s)
CONTRACT_GRANT: CNES-268
CONTRACT_GRANT: NAG2-707
CONTRACT_GRANT: NAG2-624
CONTRACT_GRANT: CNES-297
Distribution Limits
Public
Copyright
Other

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