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Acute effects of hindlimb unweighting on satellite cells of growing skeletal muscleThe proliferative behavior of satellite cells in growing rat soleus and extensor digitorum longus muscles was examined at short periods after initiation of hindlimb unweighting. Mitotic activity of satellite cells in both muscles decreased below weight-bearing control levels within 24 h of initiation of hindlimb unweighting. This satellite cell response was equal to or greater than 48 h before any atrophic morphological changes that take place in the muscles. Suppression of mitotic activity was most severe in the soleus muscle where continuous infusion of label demonstrated that virtually all mitotic activity was abolished between 3 and 5 days. The results of this study suggest that satellite cell mitotic activity is a sensitive indicator of primary atrophic changes occurring in growing myofibers and may be a predictor of future morphological changes.
Document ID
19950030311
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Schultz, Edward
Darr, Kevin C.
Macius, Allison
Date Acquired
August 16, 2013
Publication Date
January 1, 1994
Publication Information
Publication: Journal of Applied Physiology
Volume: 76
Issue: 1
ISSN: 8750-7587
Subject Category
Aerospace Medicine
Accession Number
95A61910
Funding Number(s)
CONTRACT_GRANT: NAG2-671
Distribution Limits
Public
Copyright
Other

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