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Decreased femoral arterial flow during simulated microgravity in the ratTo determine whether the blood supply to the hindlimbs of rats is altered by the tail-suspension model of weightlessness, rats were chronically instrumented for the measurement of femoral artery flow. Ultrasonic transit-time flow probes were implanted into 8-wk-old Wistar-Furth rats under ketamine-xylazine anesthesia, and, after 24 h of recovery, flow was measured in the normal ambulatory posture. Next, rats were suspended and flow was measured immediately and then daily over the next 4-7 days. Rats were subsequently returned to normal posture, and flow was monitored daily for 1-3 days. Mean arterial flow decreased immediately on the rats being suspensed and continued to decrease until a new steady state of approximately 60% of control values was attained at 5 days. On the rats returning to normal posture, flow increased to levels observed before suspension. Quantile-quantile plots of blood flow data revealed a decrease in flow during both systole and diastole. The observed decrease in hindlimb blood flow during suspension suggests a possible role in the etiology of muscular atrophy and bone loss in microgravity.
Document ID
19950030941
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Roer, Robert D.
(Univ. of North Carolina, Wilmington, NC United States)
Dillaman, Richard M.
(Univ. of North Carolina, Wilmington, NC United States)
Date Acquired
August 16, 2013
Publication Date
May 1, 1994
Publication Information
Publication: Journal of Applied Physiology
Volume: 76
Issue: 5
ISSN: 8750-7587
Subject Category
Aerospace Medicine
Accession Number
95A62540
Funding Number(s)
CONTRACT_GRANT: NAG2-391
Distribution Limits
Public
Copyright
Other

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