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Oligomerization of mononucleotides on montmorillonite: A potential approach to the prebiotic synthesis of RNAThe condensation of the 5'-phosphorimidazolide of adenosine (ImpA) on montmorillonite in a pH 8 aqueous solution yields oligomers containing up to 10 monomer units. The regiospecificity of 3',5'-phosphodiester bond formation is enhanced by addition of 10% diadenosine pyrophosphate (AppA) to the reaction mixture. A series of activated derivatives of 5'-AMP was prepared to investigate the effect of the leaving group on oligomer formation. The benzimidazole and p-dimethylamino-pyridine derivatives gave the best yields of oligomers. Factors important for oligomer formation is discussed.
Document ID
19950032203
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Ferris, James P.
(Rensselaer Polytechnic Institute, Troy, NY, US, United States)
Ertem, Goezen
(Rensselaer Polytechnic Institute, Troy, NY, US, United States)
Ding, Zi Ping
(Rensselaer Polytechnic Institute, Troy, NY, US, United States)
Prabahar, Joseph
(Rensselaer Polytechnic Institute, Troy, NY, US, United States)
Date Acquired
August 16, 2013
Publication Date
June 1, 1994
Publication Information
Publication: Origins of Life and Evolution of the Biosphere
Volume: 24
Issue: 4-Feb
ISSN: 0169-6149
Subject Category
Life Sciences (General)
Accession Number
95A63802
Funding Number(s)
CONTRACT_GRANT: NGR3-018-148
CONTRACT_GRANT: NSF CHE-85-06377
Distribution Limits
Public
Copyright
Other

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