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Effect of leaving group on the oligomerization of 5'-AMP on montmorilloniteThe oligomerization of imidazole derivative of 5'-AMP (ImpA) in the presence of montmorillonite clay yields oligomers containing up to 10 monomer units. In these reactions, the heterocyclic base, imidazole is the leaving group. In our present study, we synthesized a series of activated nucleotides of 5'AMP using other leaving groups such as pyrazole, 1,2,4-triazole, piperidine, morpholine, 4-aminopyridine, 4-methylaminopyridine, 4-dimethylaminopyridine, 2-aminobenzimidazole etc. to determine the effect of amine leaving group on the products of the oligomerization reaction. Earlier results from our laboratory showed that the presence AppA in the clay reaction of ImpA enhances the oligomerization reaction to yield higher oligomers. We also studied the effect of AppA in the clay mediated oligomerization reaction of the activated nucleotides. Oligomerization of 2-amino-benzimidazole derivative of 5'-AMP gave higher oligomers containing up to nine monomer units in the presence of AppA.
Document ID
19950032235
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Prabahar, K. Joseph
(Rensselaer Polytechnic Institute, Troy, NY, US, United States)
Ferris, James P.
(Rensselaer Polytechnic Institute, Troy, NY, US, United States)
Date Acquired
August 16, 2013
Publication Date
June 1, 1994
Publication Information
Publication: Origins of Life and Evolution of the Biosphere
Volume: 24
Issue: 4-Feb
ISSN: 0169-6149
Subject Category
Life Sciences (General)
Accession Number
95A63834
Funding Number(s)
CONTRACT_GRANT: NGR3-018-148
CONTRACT_GRANT: NSF CHE-85-06377
Distribution Limits
Public
Copyright
Other

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