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Interleukin-2 therapy reverses some immunosuppressive effects of skeletal unloadingUsing antiorthostatic suspension, we characterized hematopoietic changes that may be responsible for the detrimental effect of skeletal unloading on macrophage development. Skeletally unloaded mice had suppressed macrophage development in unloaded and loaded bones, which indicated a systemic effect. Bone marrow cells from unloaded mice secreted less macrophage colony-stimulating factor and interleukin-6 than control mice. Additionally, T-lymphocyte proliferation was reduced after skeletal unloading. We show that polyethylene glycol-interleukin-2 therapy reversed the effects of skeletal unloading on macrophage development and cell proliferation.
Document ID
19950037297
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Armstrong, Jason W.
(Kansas State Univ. Manhattan, KS, United States)
Balch, Signe
(Kansas State Univ. Manhattan, KS, United States)
Chapes, Stephen K.
(Kansas State Univ. Manhattan, KS, United States)
Date Acquired
August 16, 2013
Publication Date
August 1, 1994
Publication Information
Publication: Journal of Applied Physiology
Volume: 77
Issue: 2
ISSN: 8750-7587
Subject Category
Life Sciences (General)
Accession Number
95A68896
Funding Number(s)
CONTRACT_GRANT: DAMD17-89-Z-9039
CONTRACT_GRANT: NAGW-1197
CONTRACT_GRANT: NAGW-2328
Distribution Limits
Public
Copyright
Other

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