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Record Details

Record 38 of 4054
Spaceflight alters autonomic regulation of arterial pressure in humans
Author and Affiliation:
Fritsch-Yelle, Janice M.
Charles, John B.
Jones, Michele M.
Beightol, Larry A.
Eckberg, Dwain L.
Abstract: Spaceflight is associated with decreased orthostatic tolerance after landing. Short-duration spaceflight (4 - 5 days) impairs one neutral mechanism: the carotid baroreceptor-cardiac reflex. To understand the effects of longer-duration spaceflight on baroreflex function, we measured R-R interval power spectra, antecubital vein plasma catecholamine levels, carotid baroreceptor-cardiac reflex responses, responses to Valsalva maneuvers, and orthostatic tolerance in 16 astronauts before and after shuttle missions lasting 8 - 14 days. We found the following changes between preflight and landing day: (1) orthostatic tolerance decreased; (2) R-R interval spectral power in the 0.05- to 0.15-Hz band increased; (3) plasma norepinephrine and epinephrine levels increased; (4) the slope, range, and operational point of the carotid baroreceptor cardiac reflex response decreased; and (5) blood pressure and heart rate responses to Valsalva maneuvers were altered. Autonomic changes persisted for several days after landing. These results provide further evidence of functionally relevent reductions in parasympathetic and increases in sympathetic influences on arterial pressure control after spaceflight.
Publication Date: Oct 01, 1994
Document ID:
19950042755
(Acquired Dec 28, 1995)
Accession Number: 95A74354
Subject Category: AEROSPACE MEDICINE
Document Type: Journal Article
Publication Information: Journal of Applied Physiology; p. p. 1776-1783; (ISSN 8750-7587); 77; 4
Publisher Information: United States
Contract/Grant/Task Num: NAS9-17720; NAS9-16038; NIH-HL-22296; NAG2-408
Financial Sponsor: NASA; United States
Organization Source: NASA Johnson Space Center; Houston, TX, United States
NASA Ames Research Center; Moffett Field, CA, United States
Description: 8p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: AUTONOMIC NERVOUS SYSTEM; BARORECEPTORS; BLOOD PRESSURE; ORTHOSTATIC TOLERANCE; POWER SPECTRA; SYMPATHETIC NERVOUS SYSTEM; VALSALVA EXERCISE; AEROSPACE MEDICINE; ELECTROCARDIOGRAPHY; EPINEPHRINE; GRAVITATIONAL PHYSIOLOGY; HUMAN BEINGS; HUMAN BODY; LONG DURATION SPACE FLIGHT; NOREPINEPHRINE; SPACE SHUTTLE MISSIONS
Imprint And Other Notes: Journal of Applied Physiology vol. 77, no. 4 p. 1776-1783 October 1994
Miscellaneous Notes: Research sponsored by Dept. of Veterans Affairs
Availability Source: Other Sources
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