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Experiment K-7-29: Connective Tissue StudiesIn zero or micro-gravity, type 1 muscle fibers atrophy and lose predominance, especially in slow-twitch muscles. No increase in mononuclear cells has been observed, just as in simple denervation, where both types 1 and 2 fibers atrophy, again without infiltration of cells, but with clear satellite cell proliferation. However, extracellular matrix (ECM) degradation takes place after denervation and if re-innervation is encouraged, functional recovery to near control levels may be achieved. No information is available concerning the ECM milieu, the activation of serine proteases, their efficacy in degrading ECM components and the production of locally-derived natural protease inhibitors (serpins) in effecting surface proteolytic control. In addition, no studies are available concerning the activation of these enzymes in micro- or zero gravity or their response to muscle injury on the ground and what alterations, if any, occur in space. These studies were the basis for the experiments in Cosmos 2044.
Document ID
Document Type
Festoff, B. W. (Kansas Univ. Kansas City, KS United States)
Ilyina-Kakueva, E. I. (Institute of Biomedical Problems Moscow, USSR)
Rayford, A. R. (Veterans Administration Hospital Kansas City, MO United States)
Burkovskaya, T. E. (Institute of Biomedical Problems Moscow, USSR)
Reddy, B. R. (Veterans Administration Hospital Kansas City, MO United States)
Rao, J. S. (Veterans Administration Hospital Kansas City, MO United States)
Date Acquired
August 17, 2013
Publication Date
September 1, 1994
Publication Information
Publication: US Experiments Flown on the Soviet Biosatellite Cosmos 2044
Subject Category
Life Sciences (General)
Distribution Limits
Work of the US Gov. Public Use Permitted.
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