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Production of New Trabecular Bone in Osteopenic Ovariectomized Rats by Prostaglandin E2Serum chemistry and bone morphometry of the proximal tibial metaphysis were performed in 3 month-old double fluorescent-labeled, female Sprague-Dawley rats subjected to bilateral ovariectomy or sham surgery for 4 months prior to treatment with 0, 0.3, 1,3, or 6 mg of prostaglandin E2 (PGE2)/kg/day subcutaneously for 30 days. The 4 month postovariectomized rats possessed an osteopenic proximal tibial metaphysis with 7% trabecular area compared with controls (19%). PGE2 treatment elevated osteocalcin levels and augmented proximal tibial metaphyseal bone area in ovariectomized and sham-operated rats. Osteopenic, ovariectomized rats treated with 6 mg (PGE2)/kg/day for 30 days restored bone area to levels of agematched sham-operated rats. Morphometric analyses showed increased woven and lamellar bone area, fluorescent-labeled perimeter (osteoblastic recruitment), mineral apposition rate (osteoblastic activity), bone formation rate (BFR/BV), and longitudinal bone growth. These dramatic bone changes were all significantly increased at the doseresponse manner. This study showed that in vivo PGE2 is a powerful activator of bone remodeling, it increases both bone resorption and bone formation, and produces an anabolic effect by shifting bone balance to the positive direction. Furthermore, PGE2-induced augmentation of metaphyseal bone area in ovariectomized rats was at least two times greater than in sham-operated rats.
Document ID
19970003038
Acquisition Source
Ames Research Center
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Mori, S.
(Utah Univ. Salt Lake City, UT United States)
Jee, W. S. S.
(Utah Univ. Salt Lake City, UT United States)
Li, X. J.
(Utah Univ. Salt Lake City, UT United States)
Date Acquired
August 17, 2013
Publication Date
January 1, 1992
Publication Information
Publication: Calcified Tissue International
Volume: 50
Subject Category
Life Sciences (General)
Report/Patent Number
NAS 1.26:202471
NASA-CR-202471
Accession Number
97N70182
Funding Number(s)
CONTRACT_GRANT: DE-FG02-89ER-60764
CONTRACT_GRANT: NIH-AR-38346
CONTRACT_GRANT: NAG2-435
Distribution Limits
Public
Copyright
Public Use Permitted.
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