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Prostaglandin E2 Prevents Bone Loss and Adds Extra Bone to Immobilized Distal Femoral Metaphysis in Female RatsThe object of this study was to determine whether prostaglandin E2 (PGE2) can prevent disuse (underloading)-induced cancellous bone loss. Thirteen-month-old retired female Sprague-Dawley breeders served as controls or were subjected to right hindlimb immobilization by bandaging and simultaneously treated subcutaneously daily with 0, 1, 3, or 6 mg PGE2/kg/d for two and six weeks. Histomorphometric analyses were performed on the cancellous bone using double-fluorescent labeled, 20 micron thick, undecalcified distal femoral metaphysis sections. We found that PGE2 administration not only prevented disuse-induced bone loss, but also added extra bone to disuse cancellous bone in a dose-response manner. PGE2 prevented the disuse-induced osteopenia by stimulating more bone formation than and shortening the period of bone remodeling. It activated woven bone formation, stimulated lamellar bone formation, and increased the eroded bone surface above that caused by disuse alone. While underloading increased the remodeling period (sigma), PGE2 treatment of underloaded bone shortened the time for osteoclastic bone resorption and bone remodeling, and thus reduced the remodeling space. The study shows that PGE2 is a powerful anabolic agent that prevents disuse-induced osteopenia and adds extra bone to these same bones.
Document ID
19970004211
Acquisition Source
Ames Research Center
Document Type
Preprint (Draft being sent to journal)
Authors
Akamine, T.
(Utah Univ. Salt Lake City, UT United States)
Jee, W. S. S.
(Utah Univ. Salt Lake City, UT United States)
Ke, H. Z.
(Utah Univ. Salt Lake City, UT United States)
Li, X. J.
(Utah Univ. Salt Lake City, UT United States)
Lin, B. Y.
(Utah Univ. Salt Lake City, UT United States)
Date Acquired
August 17, 2013
Publication Date
January 1, 1992
Publication Information
Publication: Bone
Publisher: Pergamon Press
Volume: 13
ISSN: 8756-3282
Subject Category
Life Sciences (General)
Report/Patent Number
NAS 1.26:202677
NASA-CR-202677
Accession Number
97N70283
Funding Number(s)
CONTRACT_GRANT: NAG2-435
CONTRACT_GRANT: DE-ACO2-76EV-00119
CONTRACT_GRANT: DE-FG02-89ER-60764
CONTRACT_GRANT: NIH-AR-38346
Distribution Limits
Public
Copyright
Public Use Permitted.
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