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Immune Response and Function: Exercise Conditioning Versus Bed-Rest and Spaceflight DeconditioningImmune responses measured at rest immediately or some hours after exercise training (some with and some without increase in maximal oxygen uptake) gave variable and sometimes conflicting results; therefore, no general conclusions can be drawn. On the other hand, most immune responses were either unchanged (immunoglobulin, T cells, CD4+, and natural killer activity) or decreased (blood properdin, neutrophil phagocytic activity, salivary lysozymes, brain immunoglobulin A and G, and liver B lymphocytes and phytohemagglutinin activity) during prolonged bed rest. Some data suggested that exercise training during bed rest may partially ameliorate the decreased functioning of the immune system. Exercise and change in body position, especially during prolonged bed rest with plasma fluid shifts and diuresis, may induce a change in plasma protein concentration and content, which can influence drug metabolism as well as immune function. Leukocytosis, accompanied by lymphopenia and a depressed lymphocyte response, occurs in astronauts on return to Earth from spaceflight; recovery may depend on time of exposure to microgravity. It is clear that the effect of drugs and exercise used as countermeasures for microgravity deconditioning should be evaluated for their effect on an astronaut's immune system to assure optimal health and performance on long-duration space missions.
Document ID
Acquisition Source
Ames Research Center
Document Type
Reprint (Version printed in journal)
Greenleaf, J. E.
(NASA Ames Research Center Moffett Field, CA United States)
Jackson, C. G. R.
(NASA Ames Research Center Moffett Field, CA United States)
Lawless, D.
(NASA Ames Research Center Moffett Field, CA United States)
Date Acquired
August 17, 2013
Publication Date
March 1, 1994
Publication Information
Publication: Sports Medicine, Training and Rehabilitation
Publisher: Harwood Academic Publishers G.m.b.H.
Volume: 5
Subject Category
Aerospace Medicine
Report/Patent Number
NAS 1.15:112667
Accession Number
Distribution Limits
Public Use Permitted.
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