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The Anti-Emetic Properties of 1-Sulpiride in a Ground-Based Model of Space Motion SicknessL-sulpiride, at a dose of 4 mg/kg, essentially abolished motion- induced emesis in a group of 6 squirrel monkeys undergoing horizontal rotation at 25 rpm, a terrestrial model of space motion sickness (SMS). Extrapyramidal side effects were not observed. In the absence of the drug, the usual emetic response returned. In comparison while typical neuroleptics were also strongly anti-emetic, they produced a considerable degree of rigidity and akinesia.
Document ID
19970020067
Acquisition Source
Langley Research Center
Document Type
Reprint (Version printed in journal)
Authors
Miller, Joseph D.
(California Univ. Davis, CA United States)
Brizzee, Kenneth R.
(Tulane Univ. Covington, LA United States)
Date Acquired
August 17, 2013
Publication Date
August 11, 1987
Publication Information
Publication: Life Sciences
Publisher: Pergamon Journals Ltd.
Volume: 41
ISSN: 0024-3205
Subject Category
Aerospace Medicine
Report/Patent Number
NAS 1.26:204426
NASA-CR-204426
Accession Number
97N71923
Funding Number(s)
CONTRACT_GRANT: NIH-RR-00164-24
CONTRACT_GRANT: NAG2-101
CONTRACT_GRANT: NAS1-2334
Distribution Limits
Public
Copyright
Public Use Permitted.
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