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Acute Cutaneous Microvascular Flow Responses to Whole-Body Tilting in HumansThe transition from upright to head-down tilt (HDT) posture in humans increases blood pressure superior to the heart and decreases pressure inferior to the heart. Consequently, above heart level, myogenic arteriolar tone probably increases with HDT, in opposition to the withdrawal of baroreceptor-mediated sympathetic tone. We hypothesized that due to antagonism between central and local controls, the response of the facial cutaneous microcirculation to acute postural change will be weaker than that in the leg, where these two mechanisms reinforce each other. Cutaneous microvascular flow was measured by laser Doppler flowmetry simultaneously at the shin and the neck of 7 male and 3 female subjects. Subjects underwent a stepwise tilt protocol from standing control to 54 deg head-up tilt (HUT), 30 deg, 12 deg, O deg, -6 deg (HDT), -12 deg, -6 deg, O deg, 12 deg, 30 deg, 54 deg, and standing, for 30-sec periods with 10-sec transitions between postures. Flows at the shin and the neck increased significantly (P less than 0.05) from standing baseline to 12 deg HUT (252 +/- 55 and 126 +/- 9% (bar X +/- SE) of baseline, respectively). From 12 deg to -12 deg tilt, flows continued to increase at the shin (509 +/- 71% of baseline) but decreased at the neck to baseline levels (100 +/- 15% of baseline). Cutaneous microvascular flow recovered at both sites during the return to standing posture with significant hysteresis. Flow increases from standing to near-supine posture are attributed at both sites to baroreceptor-mediated vasodilation. The great dissimilarity in flow response magnitudes at the two measurement sites may be indicative of central/local regulatory antagonism above heart level and reinforcement below heart level.
Document ID
19970020729
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Breit, Gregory A. (NASA Ames Research Center Moffett Field, CA United States)
Watenpaugh, Donald E. (NASA Ames Research Center Moffett Field, CA United States)
Ballard, Richard E. (NASA Ames Research Center Moffett Field, CA United States)
Hargens, Alan R. (NASA Ames Research Center Moffett Field, CA United States)
Date Acquired
August 17, 2013
Publication Date
February 17, 1993
Publication Information
Publication: Microvascular Research
Volume: 46
ISSN: 0026-2862
Subject Category
Aerospace Medicine
Report/Patent Number
NAS 1.26:204219
NASA-CR-204219
Funding Number(s)
PROJECT: RTOP 199-14-12-04
Distribution Limits
Public
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