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Chemical Topography of Efferent Projections from the Median Preoptic Nucleus to Pontine Monoaminergic Cell Groups in the RatThis study examined efferent output from the median preoptic nucleus (MnPO) to pontine noradrenergic and serotonergic cell groups using an anterograde tracing technique (Phaseolus vulgaris leucoagglutinin, PHA-L) combined with glucose oxidase immunocytochemistry to scrotonin (5-HT) or to dopamine-(beta)-hydroxylase (DBH). Injections of PHA-L into the ventral MNPO resulted in moderate axonal labeling within the region of the B7 and B8 serotonergic groups in the dorsal raphe. PHA-L labeled fibers and punctate processes were observed in close apposition to many of the 5-HT immunoreactive neurons in these regions, In contrast, sparse terminal labeling was found within the B5 group in the raphe pontis nucleus, and only trace fiber labeling observed in the B3 and B6 groups. Efferents from the MNPO also provided moderate innervation to the A6 and A7 noradrenergic groups. PHA-L labeled punctate processes were found most frequently in close apposition to DBH-immunorcactive neurons at mid- to caudal levels of the locus coeruleus. Some labeled axons were also present within the A7 and A5 groups. Additionally, a close apposition between labeled MNPO efferents and 5-HT fibers within the lateral parabrachial nucleus was observed, The results indicate the MNPO provides a topographic innerva- tion of monoaminergic groups in the upper brainstem.
Document ID
19980223026
Acquisition Source
Headquarters
Document Type
Reprint (Version printed in journal)
Authors
Zardetto-Smith, Andrea M.
(Iowa Univ. Iowa City, IA United States)
Johnson, Alan Kim
(Iowa Univ. Iowa City, IA United States)
Date Acquired
August 18, 2013
Publication Date
January 1, 1995
Publication Information
Publication: Neuroscience Letters
Publisher: Elsevier Science Ireland Ltd.
Volume: 199
ISSN: 0304-3940
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NIH-HL-44546
CONTRACT_GRANT: NIH-HL-14338
CONTRACT_GRANT: NAG5-6171
CONTRACT_GRANT: NRSA F32HL-08349
CONTRACT_GRANT: NAGw-4358
Distribution Limits
Public
Copyright
Other

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