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Effect of Propranolol on Thyroxine-Induced Changes in Body Temperature and Metabolism During Exercise in DogsEffects of thyroxine on temperature and metabolism during exercise were studied in dogs after beta-adrenergic blockade. Dogs performed 60 min treadmill exercise of moderate intensity 5 and 72 h following thyroxine injected s. c. in a single dose of 0.1 mg/kg b.w. Thyroxine increased significantly the lipolytic response to exercise as well as blood lactate (LA) concentrations and rectal temperature (T(sub re)) during exercise as early as 5 h following the hormone administration. The changes became more pronounced 72 h after the injection. At rest T(sub re), blood FFA (free fatty acid) and LA levels in the thyroxine-treated dogs did not differ from the control values, and blood glucose was slightly, but significantly higher. Propranolol given intravenously in a dose of 0.25 mg/kg at 30 min of the exercise performed 72 h following thyroxine injection abolished the plasma FFA rise, and inhibited to a certain extent increases in T(sub re) and blood LA concentrations during the next 30 min of exercise.
Document ID
Document Type
Reprint (Version printed in journal)
Kaciuba-Uscilko, Hanna
(Polish Academy of Sciences Warsaw, Poland)
Brzezinska, Zofia
(Polish Academy of Sciences Warsaw, Poland)
Greenleaf, John E.
(Polish Academy of Sciences Warsaw, Poland)
Date Acquired
August 19, 2013
Publication Date
January 1, 1976
Publication Information
Publication: Acta Physiol. Pol.
Volume: 27
Issue: 1
Subject Category
Life Sciences (General)
Distribution Limits
Work of the US Gov. Public Use Permitted.
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