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the effects of space flight on some liver enzymes concerned with carbohydrate and lipid metabolism in ratsThe activities of about 30 enzymes concerned with carbohydrate and lipid metabolism and the levels of glycogen and of individual fatty acids were measured in livers of rats ex- posed to prolonged space flight (18.5 days) aboard COSMOS 986 Biosatellite. When flight stationary, (FS) and flight centrifuged (FC) rats were compared at recovery (R(sub 0)), decrceases in the activities of glycogen phosphorylase, alpha glycerphosphate, acyl transferase, diglyceride acyl transferase, acconitase and Epsilon-phosphogluconate dehydrogenase were noted in the weightless group (FS). The significance of these findings was strengthened since all activities, showing alterations at R(sub 0), returned to normal 25 days post-flight. Differences were also seen in levels of two liver constituents. When glycogen and total fatty acids of the two groups of flight animals were determined, differences that could be attributed to reduced gravity were observed, the FS group at R(sub 0) contained, on the average, more than twice the amount of glycogen than did controls ad a remarkable shift in the ratio of palmitate to palmitoleate were noted. These metabolic alterations appear to be unique to the weightless condition. Our data justify the conclusion that centrifugation during space flight is equivalent to terrestrial gravity.
Document ID
19990052714
Document Type
Reprint (Version printed in journal)
Authors
Abraham, S.
(Bruce Lyon Memorial Research Lab. Oakland, CA United States)
Lin, C. Y.
(Bruce Lyon Memorial Research Lab. Oakland, CA United States)
Klein, H. P.
(NASA Ames Research Center Moffett Field, CA United States)
Volkmann, C.
(NASA Ames Research Center Moffett Field, CA United States)
Date Acquired
August 19, 2013
Publication Date
August 1, 1978
Publication Information
Publication: Physiologist
Volume: 21
Issue: 4
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NAS2-9523
Distribution Limits
Public
Copyright
Other