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The Effect of Spaceflight on Cartilage Cell Cycle and DifferentiationIn vivo studies have shown that spaceflight results in loss of bone and muscle. In an effort to understand the mechanisms of these changes, cell cultures of cartilage, bone and muscle have been subjected to spaceflight to study the microgravity effects on differentiated cells. However it now seems possible that the cell differentiation process itself may be the event(s) most affected by spaceflight. For example, osteoblast-like cells have been shown to have reduced cellular activity in microgravity due to an underdifferentiated state (Carmeliet, et al, 1997). And reduced human lymphocyte growth in spaceflight was related to increased apoptosis (Lewis, et al, 1998). Which brings us to the question of whether reduced cellular activity in space is due to an effect on the differentiated cell, an effect on the cell cycle and cell proliferation, or an effect on cell death. This question has not been specifically addressed on previous flights and was the question behind die present study.
Document ID
20000021584
Acquisition Source
Ames Research Center
Document Type
Other
Authors
Doty, Stephen B.
(Hospital for Special Surgery New York, NY United States)
Stiner, Dalina
(Hospital for Special Surgery New York, NY United States)
Telford, William G.
(National Inst. of Health Bethesda, MD United States)
Date Acquired
August 19, 2013
Publication Date
January 1, 2000
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: NAG2-1184
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
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