NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Activity Dependent Signal Transduction in Skeletal MuscleThe overall goals of this project are: 1) to define the initial signal transduction events whereby the removal of gravitational load from antigravity muscles, such as the soleus, triggers muscle atrophy, and 2) to develop countermeasures to prevent this from happening. Our rationale for this approach is that, if countermeasures can be developed to regulate these early events, we could avoid having to deal with the multiple cascades of events that occur downstream from the initial event. One of our major findings is that hind limb suspension causes an early and sustained increase in intracellular Ca(2+) concentration ([Ca (2+)](sub i)). In most cells the consequences of changes in ([Ca (2+)](sub i))depend on the amplitude, frequency and duration of the Ca(2+) signal and on other factors in the intracellular environment. We propose that muscle remodeling in microgravity represents a change in the balance among several CA(2+) regulated signal transduction pathways, in particular those involving the transcription factors NFAT and NFkB and the pro-apoptotic protein BAD. Other Ca(2+) sensitive pathways involving PKC, ras, rac, and CaM kinase II may also contribute to muscle remodeling.
Document ID
20000029479
Acquisition Source
Johnson Space Center
Document Type
Other
Authors
Hamilton, Susan L.
(Baylor Coll. of Medicine Houston, TX United States)
Date Acquired
August 19, 2013
Publication Date
September 30, 1999
Publication Information
Publication: National Space Biomedical Research Institute
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
Document Inquiry

Available Downloads

There are no available downloads for this record.
No Preview Available