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NASA Sponsored Research Involving Crystallization of Biological MaterialsAn overview of NASA's plans for the performing experiments involving the crystallization of biological materials on the International Space Station (ISS) is presented. In addition, a brief overview of past work is provided as background. Descriptions of flight hardware currently available for use on the ISS are given and projections of future developments are discussed. In addition, experiment selection and funding is described. As of the flight of STS-95, these crystallization projects have proven to be some of the most successful in the history of microgravity research. The NASA Microgravity Research Division alone has flown 185 different proteins, nucleic acids, viruses, and complexes on 43 different missions. 37 of the 185 have resulted, in, diffraction patterns with higher resolution than was obtained in all previous ground based experiments. This occurred despite the fact that an average of only 41 samples per protein were flown. A number of other samples have shown improved signal to noise characteristics, i.e. relative Wilson plots, when compared to the best ground experiments. In addition, a number of experiments investigating the effects of microgravity conditions on the crystallization of biological material have been conducted.
Document ID
20000036512
Acquisition Source
Marshall Space Flight Center
Document Type
Preprint (Draft being sent to journal)
Authors
Downey, James Patton
(NASA Marshall Space Flight Center Huntsville, AL United States)
Date Acquired
September 8, 2013
Publication Date
January 1, 2000
Subject Category
Life Sciences (General)
Meeting Information
Meeting: Crystallization of Biological Macromolecules
Location: Sandestin, FL
Country: United States
Start Date: May 14, 2000
End Date: May 19, 2000
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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