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Record Details

Record 68 of 13802
Marked Exacerbation of Orthostatic Intolerance After Long vs. Short-Duration Spaceflight in Veteran Astronauts
Author and Affiliation:
Fritsch-Yelle, Janice M.(NASA Johnson Space Center, Houston, TX United States)
Reyes, Carlos(Wyle Labs., Inc., Houston, TX United States)
Perez, Sondra A.(Wyle Labs., Inc., Houston, TX United States)
Goldberger, Ary L.(Beth Israel Deaconess Medical Center, Boston, MA United States)
Ziegler, Michael G.(California Univ., San Diego, CA United States)
Paloski, William H. [Technical Monitor]
Abstract: The incidence of postflight orthostatic intolerance following short-duration spaceflight is about 20%. However, the incidence following long-duration spaceflight is unknown. We performed tilt tests on six astronauts before and after their long-duration (129 - 190 days) spaceflights and compared these data to those obtained during stand tests before and after their previous short-duration missions and also to tilt test data from 20 different short-duration (8 - 16 days) flight astronauts. Five of these six became presyncopal during tilt testing after long-duration flights: only one had become presyncopal during stand testing after short-duration flights. Five of the twenty astronauts who flew on other short-duration flights, became presyncopal during upright tilt on landing day. Long-duration presyncopal subjects had lower stroke volumes, lower cardiac outputs and higher peripheral vascular resistance than short-duration presyncopal subjects, but their heart rate responses were not different. One subject had subnormal norepinephrine release with upright posture after a long but not short flight. Plasma volume losses were not greater after long flights. Long-duration spaceflight markedly increases orthostatic intolerance, probably related to altered autonomic function.
Publication Date: Dec 01, 1999
Document ID:
20000110018
(Acquired Nov 17, 2000)
Subject Category: AEROSPACE MEDICINE
Document Type: Preprint
Contract/Grant/Task Num: NAS9-97005; NAG5-6350
Financial Sponsor: NASA Johnson Space Center; Houston, TX United States
NASA Goddard Space Flight Center; Greenbelt, MD United States
Organization Source: NASA Johnson Space Center; Houston, TX United States
Description: 2p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: No Copyright
NASA Terms: LONG DURATION SPACE FLIGHT; AUTONOMIC NERVOUS SYSTEM; ASTRONAUTS; CARDIOVASCULAR SYSTEM; AEROSPACE MEDICINE; HEAD UP TILT; HEART RATE; PLASMA LOSS; POSTURE; PHYSIOLOGICAL RESPONSES; NOREPINEPHRINE; SYNCOPE
Availability Source: Other Sources
Availability Notes: Abstract Only
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