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Human Trials of a 2-Hour Prebreathe ProtocolWe evaluate 2-hour prebreathe protocols combining simulated microgravity and exercise during prebreathe with the objective of validating a protocol for use on International Space Station (ISS). The protocol was tested with four different exercise doses during prebreathe in a multi-center trial involving three laboratories. Subject selection, Doppler monitoring techniques for venous gas emboli (VGE), test termination criteria, and definitions of decompression sickness (DCS) were standardized in all laboratories. The Phase II protocol met the accept criteria for a prebreathe procedure for use by astronauts during assembly and maintenance of the ISS Dual-cycle ergometry or light exercise individually was not sufficient to protect against DCS at acceptable levels. The combination of both was successful.
Document ID
20000110070
Acquisition Source
Johnson Space Center
Document Type
Preprint (Draft being sent to journal)
Authors
Butler, Bruce D.
(Texas Univ. Medical School TX United States)
Vann, R. D.
(Duke Univ. Durham, NC United States)
Nishi, Ronald Y.
(Defence and Civil Inst. of Environmental Medicine Canada)
Gerth, W. A.
(Duke Univ. Durham, NC United States)
Beltran, E.
(Texas Univ. Medical School TX United States)
Conkin, J.
(Baylor Coll. of Medicine Houston, TX United States)
Schneider, Suzanne
(NASA Johnson Space Center Houston, TX United States)
Loftin, K. C.
(Wyle Labs., Inc. TX United States)
Sullivan, Pat A.
(Canadian Space Agency Saint Hubert, Quebec Canada)
Homick, Jerry L.
Date Acquired
August 19, 2013
Publication Date
January 1, 2000
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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