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Increased Arginine and Ornithine Flux in Islets of Langerhans Cultured in a Microgravity Model SystemMicrogravity is associated with alterations in protein metabolism of both muscle and bone. That pancreas-derived insulin is essential to the normal maintenance of body protein balance is well known. The importance of altered endocrine pancreas function in microgravity is not yet established. We proposed to examine the influence of a microgravity model system, the High Aspect Ratio Vessel (HARV) upon islets of Langerhans from Wistar Furth rats. Islets were cultured in the HARV for 48 hr in Medium-199 and contrasted to static control islets (PLATE). Nitrogenous compounds elaborated into the media (micromoles/ml) were analyzed at 0 and 48 hr of culture and compared to PLATE with a 2-way ANOVA (HARV vs Hour).
Document ID
Document Type
Preprint (Draft being sent to journal)
Tobin, B. W. (Mercer Univ. Macon, GA United States)
Sams, C. F. (NASA Johnson Space Center Houston, TX United States)
Smith, S. M. (NASA Johnson Space Center Houston, TX United States)
Date Acquired
August 19, 2013
Publication Date
January 1, 2000
Subject Category
Space Processing
Meeting Information
Experimental Biology 2000(San Diego, CA)
Distribution Limits
Work of the US Gov. Public Use Permitted.