NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Quantifying Main Trends in Lysozyme Nucleation: The Effects of Precipitant Concentration, Supersaturation and ImpuritiesFull factorial experimental design incorporating multi-linear regression analysis of the experimental data allows quick identification of main trends and effects using a limited number of experiments. In this study these techniques were employed to identify the effect of precipitant concentration, supersaturation, and the presence of an impurity, the physiological lysozyme dimer, on the nucleation rate and crystal dimensions of the tetragonal forin of chicken egg white lysozyme. Decreasing precipitant concentration, increasing supers aturation, and increasing impurity, were found to increase crystal numbers. The crystal axial ratio decreased with increasing precipitant concentration, independent of impurity.
Document ID
20010039528
Acquisition Source
Marshall Space Flight Center
Document Type
Preprint (Draft being sent to journal)
Authors
Burke, Michael W.
(NASA Marshall Space Flight Center Huntsville, AL United States)
Leardi, Riccardo
(Dipartimento di Chimica e Tecnologie Farmaceutiche e Alimentari Genova Italy)
Judge, Russell A.
(Universities Space Research Association Huntsville, AL United States)
Pusey, Marc L.
(Universities Space Research Association Huntsville, AL United States)
Whitaker, Ann F.
Date Acquired
August 20, 2013
Publication Date
January 1, 2001
Subject Category
Solid-State Physics
Funding Number(s)
CONTRACT_GRANT: NCC8-66
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

Available Downloads

There are no available downloads for this record.
No Preview Available