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Hypergravity Effects on the Mother-Offspring System in MammalsIn 1995, ten pregnant female rats were launched on the Space Shuttle (STS-70) on Gestational day (G) 11 of their 22-day pregnancy as part of the NASA/NIH.Rodent (R)2 Experiment. Following landing on G20, fetuses were harvested from half of the dams, 0 g while the remaining five dams underwent birth. Spaceflight did not interrupt pregnancy, alter litter sizes, or affect body weights or gender ratios of the fetuses or neonates. Analyses of rats exposed to Hypergravity (HG) at 2.0-g, HG 1.75-g, HG 1.5-g were also conducted. Dams were exposed to continuous centrifugation from G I I through G20, with brief daily stops for animal health checks and maintenance. For both the G20 and Birth dams, comparable litter sizes and litter gender ratios were observed across gravity conditions. However, centrifugation-exposed (HG and RC) fetuses and neonates showed significantly lower body masses (p less than 0.05) relative to SC offspring. FIG 2.0-g offspring weighed significantly less than those in all other gravity conditions (p less than 0.05). Changes in the mothers care of the young will be discussed.
Document ID
20010048665
Acquisition Source
Ames Research Center
Document Type
Conference Paper
Authors
Ronca, April E.
(NASA Ames Research Center Moffett Field, CA United States)
Sun, Sid
Date Acquired
August 20, 2013
Publication Date
January 1, 2001
Subject Category
Aerospace Medicine
Meeting Information
Meeting: International Society for Gravitational Physiology Meeting
Location: Budapest
Country: Hungary
Start Date: April 22, 2001
End Date: April 29, 2001
Funding Number(s)
PROJECT: RTOP 121-10-40
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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