NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Body Mass Changes Associated With Hyper-Gravity are Independent of Adrenal Derived HormonesExposure to hyper-gravity results in a number of metabolic changes associated with increases in catecholamines and corticosterone. These changes result in a loss of body and fat mass. To assess the role of hormones derived from the adrenal gland in the changes we studied sham operated (SO) and adrenalectomized (ADX) male rats exposed to hyper-gravity of 2 G for 14 days. Control groups at 1 G were also studied. Urinary epinephrine (EPI) and corticosterone (CORT) were reduced in ADX animals. In response to 2 G there was an increase in urinary EPI and CORT in SO rats, while levels were unchanged in ADX animals. Both groups of animals had similar increases in urinary norepinephrine levels. The reductions of body mass gain in response to 2 G were the same in both groups. The decrease in relative fat mass was greater in ADX. Energy intake and expenditure were not different between groups. In response of returning to 1 G for 24 hours and reexposure to hyper-gravity there were no differences between SO and ADX in the changes of food and water intake, body mass or activity. The changes in metabolism with exposure to hyper-gravity do not appear to require hormones derived from the adrenal gland. The increase in lypolysis and alterations body and fat mass appear to be modulated by sympathetically derived norepinehrine.
Document ID
20010084179
Document Type
Preprint (Draft being sent to journal)
Authors
Wade, Charles E. (NASA Ames Research Center Moffett Field, CA United States)
Moran, Megan M. (NASA Ames Research Center Moffett Field, CA United States)
Wang, Tommy J. (NASA Ames Research Center Moffett Field, CA United States)
Baer, Lisa A. (NASA Ames Research Center Moffett Field, CA United States)
Yuan, Fang (NASA Ames Research Center Moffett Field, CA United States)
Fung, Cyra K. (NASA Ames Research Center Moffett Field, CA United States)
Stein, T. Peter (NASA Ames Research Center Moffett Field, CA United States)
Dalton, Bonnie P.
Date Acquired
August 20, 2013
Publication Date
January 29, 2001
Subject Category
Aerospace Medicine
Meeting Information
Experimental Biology(Orlando, FL)
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.